Profiling the gut microbiome proteins that modify bile
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Category: ResearchType: News
Source: PNNL
Date: Monday, August 28th, 2017
News Brief
August 28, 2017 
WASHINGTON, D.C. - It turns out that bile is a lot more dynamic than you might think. One of the biggest factors affecting bile, which is very important to our ability to absorb nutrients, is our diet. But another is the make-up of the community of microbes in the human gut.
Researcher Kris Brandvold of the D.O.E.'s Pacific Northwest National Lab is hunting down the exact ways that microbes affect our bile and change its function in our body. Such changes are crucial to how we absorb nutrients, how we put on weight, and even how susceptible we are to develop certain types of cancer.
Brandvold is working with Aaron Wright and colleagues to use activity-based protein profiling approaches to measure the activity of proteins modifying bile in the gut microbiome, then separate out proteins of interest and identify them. The system allows the team to gain a global view of molecular activity in a system by measuring the activity of several proteins of interest simultaneously.
"We're studying how microbes change the local environment in our gut. We're studying what the exact steps are and what enzymatic machinery is involved when gut microbiota chemically modify the bile acid pool," said Brandvold.
"We need to know what microbes are affecting the molecular signals in bile, which molecules are receiving the signals, and what the signals mean," said Brandvold as he presented his work last week at the yearly fall meeting of the American Chemical Society in Washington, D.C.
Tags: Fundamental Science, Biology, Molecular Biology and Biochemistry, Microbiology
Interdisciplinary teams at Pacific Northwest National Lab address many of America's most pressing issues in energy, the environment and national security through advances in basic and applied science. Founded in 1965, PNNL employs 4,400 staff and has an yearly budget of nearly $1 billion. It is managed and operated by Battelle for the D.O.E.'s Office of Science. As the single biggest supporter of basic research in the physical sciences in the United States, the Office of Science is working to address some of the most pressing challenges of our time. For more information on PNNL, visit the PNNL News Center, or follow PNNL on Facebook, Google+, Instagram, LinkedIn and Twitter.
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